Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase

J Med Chem. 1998 Mar 12;41(6):775-7. doi: 10.1021/jm9706675.

Authors

E A Hallinan¹, S Tsymbalov, P M Finnegan, W M Moore, G M Jerome, M G Currie, B S Pitzele

Affiliation

¹ Department of Chemistry, Searle, Monsanto, Skokie, Illinois 60077, USA.

PMID: 9526553
DOI: 10.1021/jm9706675

No abstract available

MeSH terms

Enzyme Induction / drug effects
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Fatty Alcohols / chemical synthesis*
Fatty Alcohols / chemistry
Fatty Alcohols / pharmacology
Humans
Imines / chemical synthesis*
Imines / chemistry
Imines / pharmacology
Magnetic Resonance Spectroscopy
Nitric Oxide Synthase / antagonists & inhibitors*
Nitric Oxide Synthase / biosynthesis
Nitric Oxide Synthase Type II
Stereoisomerism
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Fatty Alcohols
Imines
N-(5-amino-6,7-dihydroxyheptyl)ethanimidamide
NOS2 protein, human
Nitric Oxide Synthase
Nitric Oxide Synthase Type II